HCID 610131, compound → HCID 14031955, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8.6 g (0.06 mole) of monoethyl malonate and 10.0 g (0.048 mole) of 3,4-dihydro-4-phenylisoquinoline was stirred in a preheated oil bath at 120° C. for 45 min to give 14.0 g (98.7%) of ethyl 1,2,3,4-tetrahydro-4-phenyl-1-isoquinolineacetate as a pale yellow syrup. The ester was used in the next step without further purification.

Provenance & Evidence