HRID986456

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(=O)OC(C)C

HCID3951175

1-Methylethyl 2-[(3-nitrophenyl)methylene]-3-oxobutanoate

C14H15NO5

结构：C/C(N)=C/C(=O)OCCOC/C(C)=C/c1ccc(Cc2cccnc2)cc1

HCID70415663

未命名化合物

PRODUCTS

生成物

结构：CC1=C(C(=O)OCCOC/C(C)=C/c2ccc(Cc3cccnc3)cc2)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC(C)C)=C(C)N1

HCID14032946

未命名化合物

收率 75.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

In 1.36 ml of isopropanol were dissolved 340 mg of 2-[(E)-3-[4-(pyridin-3-ylmethyl)phenyl]-2-methylallyloxy]ethyl 3-aminocrotonate and 257 mg of isopropyl 2-(3-nitrobenzylidene)acetoacetate, and the resulting solution was subjected to reaction under refulx for 2 hours. The reaction mixture was thereafter stirred with ice-cooling, and the crystals thus precipitated were collected by filtration to obtain 440 mg (yield 75.8%) of 3-[2-[(E)-3-[4-(pyridin-3-ylmethyl)phenyl]-2-methylallyloxy]ethyl] 5-isopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate having a melting point of 124°-126° C. The physical properties of this product were identical with those of the compound obtained in Example 29.

WORKUP

后处理

customthe resulting solution was subjected to reaction under refulx for 2 hours
temperaturecooling
customthe crystals thus precipitated
filtrationwere collected by filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d54418f5259048659a38d1699cbc35c8
来源数据集: uspto-grants-1987_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04713387
来源说明: uspto-grants-1987_12

反应 SMILES

[NH2:1]/[C:2](/[CH3:27])=[CH:3]\[C:4]([O:6][CH2:7][CH2:8][O:9][CH2:10]/[C:11](/[CH3:26])=[CH:12]/[C:13]1[CH:18]=[CH:17][C:16]([CH2:19][C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)=[CH:15][CH:14]=1)=[O:5].[N+:28]([C:31]1[CH:32]=[C:33]([CH:45]=[CH:46][CH:47]=1)[CH:34]=[C:35]([C:42]([CH3:44])=O)[C:36]([O:38][CH:39]([CH3:41])[CH3:40])=[O:37])([O-:30])=[O:29]>C(O)(C)C>[CH3:27][C:2]1[NH:1][C:42]([CH3:44])=[C:35]([C:36]([O:38][CH:39]([CH3:41])[CH3:40])=[O:37])[CH:34]([C:33]2[CH:45]=[CH:46][CH:47]=[C:31]([N+:28]([O-:30])=[O:29])[CH:32]=2)[C:3]=1[C:4]([O:6][CH2:7][CH2:8][O:9][CH2:10]/[C:11](/[CH3:26])=[CH:12]/[C:13]1[CH:14]=[CH:15][C:16]([CH2:19][C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)=[CH:17][CH:18]=1)=[O:5]