Ethylamine → HCID 178463639, compound

HRID 986501Notes

Reaction equation

HRID 986501 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:18]=[C:17]2[N:8]([C:9](SC)=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1.[CH2:21]([NH2:23])[CH3:22]>C(O)C>[CH2:21]([N:23]=[C:9]1[N:8]2[N:7]=[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[N:18]=[C:17]2[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:10]1)[CH3:22]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 11065899HCID 11065899, compound

Product 1

HCID 178463639HCID 178463639, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(2-Furyl)-5-methylthio-[1,2,4]triazolo[1,5-c]quinazoline (1.41 g) is placed in a stainless steel pressure vessel with ethanol (200 ml) and 70% aqueous ethylamine (100 ml) and heated to an outside temperature of 150°. It reaches a pressure of 100 p.s.i. and is maintained at that pressure and temperature for 16 hours. It is cooled and the material concentrated to dryness at reduced pressure The residual solid is recrystallized from methanol to afford pure 5-ethylimino-2-(2-furyl)-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazoline, mp 133°-135°.

Workup

  1. temperatureheated to an outside temperature of 150°
  2. temperatureand is maintained at that pressure and temperature for 16 hours
  3. temperatureIt is cooled
  4. concentrationthe material concentrated to dryness at reduced pressure The residual solid
  5. customis recrystallized from methanol

Sources & evidence

ORD record
ord-f56421735e884917a4ea21af4a4cb9cf
Source dataset
uspto-grants-1987_12
Patent number
US04713383

Reaction notes

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