Ammonia → HCID 178509074, compound

HRID 986502Notes

Reaction equation

HRID 986502 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:18]=[C:17]2[N:8]([C:9](SC)=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1.[NH3:21]>[OH-].[NH4+]>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:18]=[C:17]2[N:8]([C:9](=[NH:21])[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11065899HCID 11065899, compound

Product 1

HCID 178509074HCID 178509074, compound

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent

Procedure

As in Example 37, 2-(2-furyl)-5-methylthio-[1,2,4]triazolo[1,5-c]quinazoline is reacted with ammonium hydroxide (200 ml) saturated with ammonia at 0° in the stainless steel pressure vessel at 150° and 220 p.s.i. over six hours to afford 2-(2-furyl)-5-imino-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazoline, mp 282°-285° after methanol recrystallization.

Sources & evidence

ORD record
ord-00dad2a91b3b4b78a46bfa2ee0c2054b
Source dataset
uspto-grants-1987_12
Patent number
US04713383

Reaction notes

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