Ammonia → HCID 178509083, compound

Participants

Reaction Steps

Concentrated aqueous ammonium hydroxide (50 ml) in a stainless steel pressure vessel is saturated with gaseous ammonia at 0° and 5,9-dichloro-2-(2-tetrahydrofuryl)[1,2,4]triazolo[1,5-c]-quinazoline (1.22 g) added. The mixture is heated over six hours at an outside temperature of 150°, cooled and filtered. The precipitate is washed with water and dried under high vacuum to afford pure 9-chloro-5-imino-2-(2-tetrahydrofuryl)-5,6-dihydro-[1,2,4]triazolo[1,5-c]-quinazoline (0.45 g), mp 203°-206°. The starting material is prepared as follows:

Provenance & Evidence