Ammonia → HCID 178509083, compound

HRID 986503Notes

Reaction equation

HRID 986503 reaction equation
[NH3:1].Cl[C:3]1[N:12]2[N:13]=[C:14]([CH:16]3[CH2:20][CH2:19][CH2:18][O:17]3)[N:15]=[C:11]2[C:10]2[CH:9]=[C:8]([Cl:21])[CH:7]=[CH:6][C:5]=2[N:4]=1>[OH-].[NH4+]>[Cl:21][C:8]1[CH:7]=[CH:6][C:5]2[NH:4][C:3](=[NH:1])[N:12]3[N:13]=[C:14]([CH:16]4[CH2:20][CH2:19][CH2:18][O:17]4)[N:15]=[C:11]3[C:10]=2[CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14031947HCID 14031947, compound

Product 1

HCID 178509083HCID 178509083, compound

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent

Procedure

Concentrated aqueous ammonium hydroxide (50 ml) in a stainless steel pressure vessel is saturated with gaseous ammonia at 0° and 5,9-dichloro-2-(2-tetrahydrofuryl)[1,2,4]triazolo[1,5-c]-quinazoline (1.22 g) added. The mixture is heated over six hours at an outside temperature of 150°, cooled and filtered. The precipitate is washed with water and dried under high vacuum to afford pure 9-chloro-5-imino-2-(2-tetrahydrofuryl)-5,6-dihydro-[1,2,4]triazolo[1,5-c]-quinazoline (0.45 g), mp 203°-206°. The starting material is prepared as follows:

Workup

  1. temperatureThe mixture is heated over six hours at an outside temperature of 150°
  2. temperaturecooled
  3. filtrationfiltered
  4. washThe precipitate is washed with water
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-8fb24115883a44b9bd8ba4c47f44049c
Source dataset
uspto-grants-1987_12
Patent number
US04713383

Reaction notes

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