Ammonia → HCID 178509082, compound

HRID 986504Notes

Reaction equation

HRID 986504 reaction equation
[NH3:1].[Cl:2][C:3]1[CH:12]=[CH:11][C:10]2[N:9]=[C:8](SC)[N:7]3[N:15]=[C:16]([C:18]4[O:19][CH:20]=[CH:21][CH:22]=4)[N:17]=[C:6]3[C:5]=2[CH:4]=1>[OH-].[NH4+]>[Cl:2][C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8](=[NH:1])[N:7]3[N:15]=[C:16]([C:18]4[O:19][CH:20]=[CH:21][CH:22]=4)[N:17]=[C:6]3[C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14031946HCID 14031946, compound

Product 1

HCID 178509082HCID 178509082, compound

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent

Procedure

A mixture of concentrated aqueous ammonium hydroxide (300 ml) saturated with ammonia gas at 0° and 9-chloro-2-(2-furyl)-5-methylthio[1,2,4]triazolo[1,5-c]quinazoline (5.7 g) in a stainless steel pressure vessel is heated at an outside temperature of 150° over 18 hours, during which time the pressure rises to 250 p.s.i. The reaction mixture is cooled and the solid material collected, washed with water and air dried. The 9-chloro-2-(2-furyl)-5-imino-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazoline thus obtained (2.9 g, mp 269°-271°) is converted to the methanesulphonate salt by dissolution in 2-methoxyethanol (150 ml) followed by methanesulphonic acid (0.66 ml) and dry ether (25 ml) to afford the pure salt identical to that from Example 32.

Workup

  1. temperatureThe reaction mixture is cooled
  2. customthe solid material collected
  3. washwashed with water and air
  4. customdried

Sources & evidence

ORD record
ord-6c755ca033fd4be1ac8eb1032d5cda7e
Source dataset
uspto-grants-1987_12
Patent number
US04713383

Reaction notes

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