Hydrochloric Acid → HCID 14075275, compound

HRID 986568Notes

Reaction equation

HRID 986568 reaction equation
[CH2:1]([C:3]1[N:4]([CH3:21])[C:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:6]([C:12](=[O:14])[CH:13]=1)[C:7]([O:9]CC)=[O:8])[CH3:2].Cl>[OH-].[Na+]>[CH2:1]([C:3]1[N:4]([CH3:21])[C:5]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[C:6]([C:12](=[O:14])[CH:13]=1)[C:7]([OH:9])=[O:8])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14075274HCID 14075274, compound

Product 1

HCID 14075275HCID 14075275, compoundYield 100.8%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

2.2 g of ethyl 6-ethyl-1-methyl-2-phenyl-4-oxonicotinate is suspended in 35 ml of 5% aqueous sodium hydroxide solution. The resulting suspension is heated on a steambath for 4 hours, cooled and acidified with dilute HCl to yield 2.0 g of 6-ethyl-1-methyl-2-phenyl-4-oxonicotinic acid. mp (CH3CN)=244°-245° C.

Workup

  1. temperatureThe resulting suspension is heated on a steambath for 4 hours
  2. temperaturecooled

Sources & evidence

ORD record
ord-1085031af1fa4201b21f6e95c5c36386
Source dataset
uspto-grants-1987_12
Patent number
US04714492

Reaction notes

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