Water → HCID 10404462, compound

HRID 986620Notes

Reaction equation

HRID 986620 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)[C:5]2[N:11]=[CH:10][N:9]=[C:8]([S:12][CH3:13])[C:6]=2[N:7]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.O>CS(C)=O>[CH3:13][S:12][C:8]1[C:6]2[N:7]=[C:2]([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:3]=[C:4]([N:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)[C:5]=2[N:11]=[CH:10][N:9]=1

Participants

5

Reactant 3

HCID 962WaterHCID 4837PiperazineHCID 13592630HCID 13592630, compound

Product 1

HCID 10404462HCID 10404462, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

2.8 g (0.01 mol) of 2-chloro-8-methylthio-4-pyrrolidino-pyrimido[5,4-d]pyrimidine is dissolved warm in 300 ml of dimethylsulphoxide and then a solution of 4.3 g (0.05 mol) of piperazine is added. After being stirred for 1 hour at ambient temperature the solution is poured into 1.5 liters of water. The precipitate obtained is suction filtered, washed with water and dried.

Workup

  1. customThe precipitate obtained
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-7d575089858e425283cdd9ccd0ab50e5
Source dataset
uspto-grants-1987_12
Patent number
US04714698

Reaction notes

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