Ammonium Hydroxide → HCID 178465830, compound

HRID 986642Notes

Reaction equation

HRID 986642 reaction equation
Cl([O-])(=O)(=O)=O.C([NH:9][C:10]1[O:11][CH2+:12]([CH3:25])[C:13]2[CH:19]=[C:18]([O:20][CH2:21][CH3:22])[C:17]([O:23][CH3:24])=[CH:16][C:14]=2[CH:15]=1)(=O)C.[OH-].[NH4+]>O>[CH2:21]([O:20][C:18]1[CH:19]=[C:13]2[C:14]([CH:15]=[C:10]([OH:11])[N:9]=[C:12]2[CH3:25])=[CH:16][C:17]=1[O:23][CH3:24])[CH3:22]

Participants

3

Reactant 1

HCID 14923Ammonium Hydroxide

Product 1

HCID 178465830HCID 178465830, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To an ice-cooled slurry of 36.37 grams of 3-acetamido-7-ethoxy-6-methoxy-1-methyl-2-benzopyrylium perchlorate (0.1 mol) in water (400 ml) was slowly added 80 ml of concentrated ammonium hydroxide over a 10 minute period. The mixture was stirred for additional 30 minutes. The light yellow precipitate that formed was filtered, washed with water and dried to provide 23 grams of the crude title 3-isoquinolinol (100%). Recrystallization from methanol/chloroform mixture (2000 ml:700 ml) provided 18.7 grams (81.3%) of pure title 3-isoquinolinol having a melting point of 235°-240° C.(d).

Workup

  1. customover a 10 minute
  2. customThe light yellow precipitate that formed
  3. filtrationwas filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-ec0776dbb5374b679cd448d38e6e3beb
Source dataset
uspto-grants-1987_12
Patent number
US04714705

Reaction notes

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