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Boron trifluoride etherate → 2-fluoromethyl-3-(2-methyl-4-fluorophenyl)-6-nitro-4(3H)-quinazolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Boron trifluoride etherate | HCID 8000 | — |
| 反応物 | N-(2-fluoroacetamido-5-nitrobenzoyl)-2-methyl-4-fluoroaniline | HCID 13376458 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-fluoromethyl-3-(2-methyl-4-fluorophenyl)-6-nitro-4(3H)-quinazolinone | HCID 13376466 | 79.1% |
反応手順
4.0 g of N-(2-fluoroacetamido-5-nitrobenzoyl)-2-methyl-4-fluoraniline, 3.5 g of boron trifluoride etherate and 30 ml of acetic acid are treated in the same manner as described in Example 1-(2), whereby 3.0 g of 2-fluoromethyl-3-(2-methyl-4-fluorophenyl)-6-nitro-4(3H)-quinazolinone are obtained as colorless prisms.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04714702 |
| 出典データセット | uspto-grants-1987_12 |
| ORD ID | ord-89313873c7094478aba55d719ab59def |
| 出典メモ | uspto-grants-1987_12 |