1-(2-Methoxyphenyl)piperazine → HCID 15598864, compound

Participants

Reaction Steps

Four hundred miligrams of sodium carbonate was added to 1.5 g of 7-amino-3-(2-chloroethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione, 1.4 g of 1-(2-methoxyphenyl)piperazine and 1.4 ml of dimethylformamide to react at 80° C. for 50 hours. The reaction liquid was concentrated and the resultant residue was purified through the silica gel chromatography to obtain 0.95 g of the titled compound (yield: 38%).

Provenance & Evidence