1-(2-Methoxyphenyl)piperazine → HCID 15598864, compound

HRID 986743Notes

Reaction equation

HRID 986743 reaction equation
C(=O)([O-])[O-].[Na+].[Na+].[NH2:7][C:8]1[CH:17]=[C:16]2[C:11]([C:12](=[O:22])[N:13]([CH2:19][CH2:20]Cl)[C:14](=[O:18])[NH:15]2)=[CH:10][CH:9]=1.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>CN(C)C=O>[CH3:23][O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[N:31]1[CH2:36][CH2:35][N:34]([CH2:20][CH2:19][N:13]2[C:12](=[O:22])[C:11]3[C:16](=[CH:17][C:8]([NH2:7])=[CH:9][CH:10]=3)[NH:15][C:14]2=[O:18])[CH2:33][CH2:32]1

Participants

5

Reactant 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 10340Sodium CarbonateHCID 20156270HCID 20156270, compound

Product 1

HCID 15598864HCID 15598864, compoundYield 38.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Four hundred miligrams of sodium carbonate was added to 1.5 g of 7-amino-3-(2-chloroethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione, 1.4 g of 1-(2-methoxyphenyl)piperazine and 1.4 ml of dimethylformamide to react at 80° C. for 50 hours. The reaction liquid was concentrated and the resultant residue was purified through the silica gel chromatography to obtain 0.95 g of the titled compound (yield: 38%).

Workup

  1. customto react at 80° C. for 50 hours
  2. customThe reaction liquid
  3. concentrationwas concentrated
  4. customthe resultant residue was purified through the silica gel chromatography

Sources & evidence

ORD record
ord-77b1c48664b346d8b8a8e9a9e94a262b
Source dataset
uspto-grants-1987_12
Patent number
US04716161

Reaction notes

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