Urea → HCID 15598866, compound

HRID 986744Notes

Reaction equation

HRID 986744 reaction equation
N[C:2](N)=[O:3].[CH3:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][NH:21][C:22](=[O:34])[C:23]2[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:32])[CH3:31])=[CH:25][C:24]=2[NH2:33])[CH2:15][CH2:14]1>>[CH3:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:13]1[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][N:21]2[C:22](=[O:34])[C:23]3[C:24](=[CH:25][C:26]([NH:29][C:30](=[O:32])[CH3:31])=[CH:27][CH:28]=3)[NH:33][C:2]2=[O:3])[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 1176UreaHCID 20156268HCID 20156268, compound

Product 1

HCID 15598866HCID 15598866, compoundYield 60%

Procedure

Four hundred and forty miligrams of urea was added to 1.5 g of 1-(2-methoxyphenyl)-4-[2-(4-acetylamino-2-aminobenzoyl)aminoethyl]piperazine to react at 160° C. for 8 hours. The reaction liquid was extracted with chloroform and purified through the silica gel chromatography to obtain 0.96 g of the titled compound (yield: 60%).

Workup

  1. customto react at 160° C. for 8 hours
  2. customThe reaction liquid
  3. extractionwas extracted with chloroform
  4. custompurified through the silica gel chromatography

Sources & evidence

ORD record
ord-cdc1756fef864bb59587a2e10d59a2a0
Source dataset
uspto-grants-1987_12
Patent number
US04716161

Reaction notes

Loading…