Methanesulfonyl chloride → HCID 20156425, compound

HRID 986764Notes

Reaction equation

HRID 986764 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([OH:9])[CH:6]=[CH:5][C:4]=1[C:10]1[N:11]=[C:12]2[CH:17]=[CH:16][C:15](=[O:18])[NH:14][N:13]2[CH:19]=1.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][S:21]([CH3:20])(=[O:23])=[O:22])[CH:6]=[CH:5][C:4]=1[C:10]1[N:11]=[C:12]2[CH:17]=[CH:16][C:15]([O:18][S:21]([CH3:20])(=[O:23])=[O:22])=[N:14][N:13]2[CH:19]=1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 13654487HCID 13654487, compound

Product 1

HCID 20156425HCID 20156425, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent2×

Procedure

0.3 g (1.17 mmol) of 2-(2-Methoxy-4-hydroxyphenyl)-5H-imidazo[1,2-b]pyridazin-6-one are dissolved in 10 ml of 1N sodium hydroxide solution. At 20° C., 1.3 g (1.17 mmol) of methanesulphonic acid chloride is added dropwise. By simultaneously adding 2N sodium hydroxide solution the pH is kept at 10-11.

Sources & evidence

ORD record
ord-e4c488d541d74fbd98ff39f1a0a84615
Source dataset
uspto-grants-1987_12
Patent number
US04716169

Reaction notes

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