Methyl iodide → HCID 13670617, compound

HRID 986765Notes

Reaction equation

HRID 986765 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[CH:16]=2)=[C:4]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])[CH:3]=1.[C:22](=O)([O-])[O-].[K+].[K+].CI>CS(C)=O>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[CH:16]=2)=[C:4]([N:17]([CH3:22])[S:18]([CH3:21])(=[O:20])=[O:19])[CH:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 13670618HCID 13670618, compound

Product 1

HCID 13670617HCID 13670617, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

1.1 g (3.6 mmol) of 2-(4-Hydroxy-2-methylsulphonamido-phenyl)-imidazo[1,2-a]pyridine are dissolved in 10 ml of dimethylsulphoxide, then 0.6 g (4.3 mmol) of potassium carbonate and 1.1 ml (18 mmol) of methyliodide are added. The mixture is stirred at ambient temperature for one hour. It is poured onto about 100 ml of ice water and the precipitate is suction filtered. It is then washed with water.

Workup

  1. filtrationfiltered
  2. washIt is then washed with water

Sources & evidence

ORD record
ord-9044f7f354db4a36af6e0846f3519bb2
Source dataset
uspto-grants-1987_12
Patent number
US04716169

Reaction notes

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