HCID 20156419, compound → HCID 20156406, compound

HRID 986769Notes

Reaction equation

HRID 986769 reaction equation
[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][N:14]3[CH:19]=2)=[C:7]([O:20][CH3:21])[CH:6]=1)C(C)=O>Cl>[NH2:1][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][N:14]3[CH:19]=2)=[C:7]([O:20][CH3:21])[CH:6]=1

Participants

3

Reactant 1

HCID 20156419HCID 20156419, compound

Product 1

HCID 20156406HCID 20156406, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

0.3 g (1 mmol) of 2-(4-Acetamino-2-methoxyphenyl)-imidazo[1,2-b]pyridazine are heated for 11/2 hours in 20 ml of 6N hydrochloric acid over a steam bath. After cooling and filtration, the residue is made alkaline with conc. ammonia. The product precipitated is suction filtered, washed with water and dried at 100° C. over potassium hydroxide in a drying gun.

Workup

  1. temperatureAfter cooling
  2. filtrationfiltration
  3. customThe product precipitated
  4. filtrationfiltered
  5. washwashed with water
  6. dry with materialdried at 100° C. over potassium hydroxide in a drying gun

Sources & evidence

ORD record
ord-39eb9d0d76f845f88106ebeecf0c1222
Source dataset
uspto-grants-1987_12
Patent number
US04716169

Reaction notes

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