HCID 20156388, compound → HCID 178428805, compound

HRID 986817Notes

Reaction equation

HRID 986817 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[NH:7][C:8]2[CH:14]=[C:13]([NH:15]/[C:16](/[CH3:21])=[CH:17]\[C:18]([O-:20])=O)[CH:12]=[CH:11][C:9]=2[N:10]=1>C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[NH:7][C:8]2=[C:14]3[C:13](=[CH:12][CH:11]=[C:9]2[N:10]=1)[N:15]=[C:16]([CH3:21])[CH:17]=[C:18]3[OH:20]

Participants

3

Reactant 1

HCID 20156388HCID 20156388, compound

Product 1

HCID 178428805HCID 178428805, compoundYield 75.4%

Reagents, catalysts & solvents 1

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)Solvent

Procedure

To a preheated (230°) solution of Dowtherm (500 ml) is added portion-wise 3-[[2-(2-furyl)-5-benzimidazolyl]amino]crotonate (38.5 g, 0.1 mole). After the addition is complete the reaction mixture is kept at 230° for 15 minutes, then decanted into a beaker to form, upon cooling, a tan precipitate. The precipitate is filtered and washed with hexane to give 20 g (74 percent) of tan solid. Recrystallization from CH3NO2 gives m.p. 280°-282°. Anal. Calcd. for C15H11N3O2 -1/4H2O: C, 66.78; H, 4.30; N, 15.58. Found: C, 66.56; H, 4.43; N, 15.40.

Workup

  1. additionAfter the addition
  2. customdecanted into a beaker
  3. customto form
  4. temperatureupon cooling
  5. filtrationThe precipitate is filtered
  6. washwashed with hexane

Sources & evidence

ORD record
ord-f4e820cdb68447078b0495bd01856042
Source dataset
uspto-grants-1987_12
Patent number
US04716168

Reaction notes

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