Hydrochloric Acid → HCID 178463964, compound
Reaction equation
[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[C:12](Cl)[CH:11]=1)([CH3:9])[CH3:8])[CH3:3].Cl>>[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C@H:10]1[CH2:15][CH2:14][C@H:13]([NH2:16])[CH2:12][CH2:11]1)([CH3:9])[CH3:8])[CH3:3]Participants
3
Procedure
5.1 Parts of 2-amino-6-(4-amino-3-chlorophenyl)-6-methylheptane were hydrogenated and worked up to the procedure of Example 1 using 60 parts of 1N aqueous hydrochloric acid and 1.0 parts of Nishimura catalyst. The hydrogenation, which ceased after 48 hours and which represented a 126% theory uptake, gave on distillation 4.0 parts of cis and trans 2-amino-6-(4-aminocyclohexyl)-6-methylheptane b16 160°-5°. Spectroscopic analysis showed that the ratio of cis and trans isomers was 3 to 1 parts respectively.
Sources & evidence
- ORD record
- ord-67f32b1c4bb6466297a0e2220bfdf36a
- Source dataset
- uspto-grants-1987_12
- Patent number
- US04716248
Reaction notes
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