Hydrochloric Acid → HCID 20156708, compound

HRID 986852Notes

Reaction equation

HRID 986852 reaction equation
[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[C:12]([CH2:17][CH3:18])[CH:11]=1)([CH3:9])[CH3:8])[CH3:3].Cl.[H][H]>>[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([CH:10]1[CH2:15][CH2:14][CH:13]([NH2:16])[CH:12]([CH2:17][CH3:18])[CH2:11]1)([CH3:8])[CH3:9])[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 20156728HCID 20156728, compoundHCID 178418361HCID 178418361, compound3×

Product 1

HCID 20156708HCID 20156708, compound

Procedure

10.0 Parts of 2-amino-6-(4-amino-3-ethylphenyl)-6-methylheptane in 120 parts of 1N aqueous hydrochloric acid were shaken with hydrogen at room temperature and atmospheric pressure with 1.0 parts Nishimura catalyst. After 46% of theory hydrogen had been taken up in 18 hours a further 1.0 parts of catalyst was added and 96% of theory hydrogen uptake was reached in the next 15 hours. The hydrogenation which ceased at 110% theory during the next 24 hours following a final 1.0 part catalyst addition, was worked up according to Example 1, and gave on distillation 8.8 parts of 2-amino-6-(4-amino-3-ethylcyclohexyl)-6-methylheptane b12 176°-80° with the following percentage composition by weight.

Workup

  1. additiona further 1.0 parts of catalyst was added
  2. customwas reached in the next 15 hours
  3. customceased at 110% theory during the next 24 hours
  4. additiona final 1.0 part catalyst addition

Sources & evidence

ORD record
ord-ee2afb8e6c5d4516bc6b131b236a4ff8
Source dataset
uspto-grants-1987_12
Patent number
US04716248

Reaction notes

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