反应详情

2 g (8 mmol) of α-N-(4-nitrophenyl)amino-ε-caprolactam are partially dissolved in 40 ml of 95° ethanol in a 150 ml three-necked flask equipped with a thermometer and a reflux condenser. 2 g of palladium-on-charcoal (10% active and 50% moisture) are then introduced, followed by 20 ml of cyclohexene. The mixture is brought to reflux for 3 hours and is then cooled, before being filtered through celite. After having run approximately 6 ml (˜3.5 eq) of 5N hydrochloric acid onto the filtrate, the latter is evaporated to dryness and the residue is taken up in ethanol and precipitated from acetone. After filtration, 1.9 g of a white product are obtained, i.e. a final yield of 81%.

1. customequipped with a thermometer and a reflux condenser
2. temperatureto reflux for 3 hours
3. temperatureis then cooled
4. filtrationbefore being filtered through celite
5. customthe latter is evaporated to dryness
6. customprecipitated from acetone
7. filtrationAfter filtration, 1.9 g of a white product
8. customare obtained