1-[4-[(4-Fluorophenyl)methyl]phenyl]piperazine → 5-[3-(4-(4-(4-Fluorophenyl)methylphenyl)piperazin-1-yl)propyl]sulfonyl-2,3,4,5-tetrahydro-1,5-benzoxazepine

HRID 987Notes

Reaction equation

HRID 987 reaction equation
Cl[CH2:2][CH2:3][CH2:4][S:5]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[O:12][CH2:11][CH2:10][CH2:9]1)(=[O:7])=[O:6].[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)=[CH:29][CH:28]=2)=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:21]=[CH:22][C:23]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH2:34][CH2:35][N:36]([CH2:2][CH2:3][CH2:4][S:5]([N:8]4[C:14]5[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=5[O:12][CH2:11][CH2:10][CH2:9]4)(=[O:7])=[O:6])[CH2:37][CH2:38]3)=[CH:29][CH:28]=2)=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 15199981-[4-[(4-Fluorophenyl)methyl]phenyl]piperazineHCID 196942775-(3-Chloropropylsulfonyl)-2,3,4,5-tetrahydro-1,5-benzoxazepine

Product 1

HCID 196942475-[3-(4-(4-(4-Fluorophenyl)methylphenyl)piperazin-1-yl)propyl]sulfonyl-2,3,4,5-tetrahydro-1,5-benzoxazepine

Procedure

The compound (17) synthesized in Reference Example 17 and the compound (5) synthesized in Reference Example 5 were used to produce the above compound in the same way as Example 1.

Workup

  1. customto produce the above compound in the same way as Example 1

Sources & evidence

ORD record
ord-9fdee47e3af1400fb5eacb1be913c88c
Source dataset
uspto-grants-1998_03
Patent number
US05723475

Reaction notes

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