反应详情

To a mixture of 5-bromofuroic acid (0.19 g) and carbonyl diimidazole (CDI) in dichloromethane was added (3-chloro-5-trifluoromethyl-2-pyridyl)methylamine and the mixture was stirred at room temperature overnight. The mixture was washed with 2M hydrochloric acid, then saturated sodium bicarbonate, dried (MgSO4) and evaporated to give the title product, m.p. 77.8° C.

1. washThe mixture was washed with 2M hydrochloric acid
2. dry with materialsaturated sodium bicarbonate, dried (MgSO4)
3. customevaporated