HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-2-furanecarboxylic acid → N-[(3-Chloro-5-trifluoromethyl-2-pyridyl)methyl]-5-bromofuramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-2-furanecarboxylic acid | HCID 68511 | — |
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Reactant | (3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanamine | HCID 11085087 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[(3-Chloro-5-trifluoromethyl-2-pyridyl)methyl]-5-bromofuramide | HCID 22988183 | — |
Reaction Steps
To a mixture of 5-bromofuroic acid (0.19 g) and carbonyl diimidazole (CDI) in dichloromethane was added (3-chloro-5-trifluoromethyl-2-pyridyl)methylamine and the mixture was stirred at room temperature overnight. The mixture was washed with 2M hydrochloric acid, then saturated sodium bicarbonate, dried (MgSO4) and evaporated to give the title product, m.p. 77.8° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06630495B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-7378f91fee044bb1bc0efdd366d028ff |
| Source note | uspto-grants-2003_10 |