Water → HCID 22988144, compound

HRID 987065Notes

Reaction equation

HRID 987065 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11](Cl)(=[O:13])=[O:12].Cl.N[C:17]1[CH:26]=[CH:25][C:20]([C:21]([O:23][CH3:24])=[O:22])=[CH:19][N:18]=1.O.[N:28]1C=CC=CC=1>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:28][C:19]1[C:20]([C:21]([O:23][CH3:24])=[O:22])=[CH:25][CH:26]=[CH:17][N:18]=1)(=[O:13])=[O:12]

Participants

5

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 71252-Naphthalenesulfonyl chlorideHCID 22988139180693-67-8

Product 1

HCID 22988144HCID 22988144, compoundYield 75%

Procedure

5.9 g (26 mmol) of naphthalene-2-sulfonyl chloride were added in portions at room temperature to 4.7 g (25 mmol) of methyl 6-aminonicotinate hydrochloride in 100 ml of dry pyridine. The entire mixture was then stirred at room temperature for 16 h. The reaction solution was then poured onto 500 ml of water and the precipitate obtained was filtered off with suction. 6.4 g (75%) of the product were obtained.

Workup

  1. customthe precipitate obtained
  2. filtrationwas filtered off with suction

Sources & evidence

ORD record
ord-378b7c5cc9b34b0f8e1fa903d1495c07
Source dataset
uspto-grants-2003_10
Patent number
US06630493B1

Reaction notes

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