反应详情

Compound (c) (1.905 g; 6.18 mmole) was dissolved in acetonitrile (13 ml) and added dropwise to a mixture of ethyl 2-ethoxy-3-(3-hydroxyphenyl)-propanoate (1.47 g; 6.18 mmole) and potassium carbonate (2.56 g; 18.54 mmole) in acetonitrile (15 ml). The mixture was refluxed for 5 hours, then the solvent was evaporated in vacuo and water was added. The mixture was extracted twice with dichloromethane, dried (sodium sulfate), filtered and the solvent was evaporated in vacuo. Purification by chromatography on silica gel using diethyl ether/petroleum ether (gradient 33% to 100% diethyl ether) gave 1.80 g (yield 65%) of the desired product.

1. temperatureThe mixture was refluxed for 5 hours
2. customthe solvent was evaporated in vacuo and water
3. additionwas added
4. extractionThe mixture was extracted twice with dichloromethane
5. dry with materialdried (sodium sulfate)
6. filtrationfiltered
7. customthe solvent was evaporated in vacuo
8. customPurification by chromatography on silica gel