HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → Triphenylphosphine Oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | Methyl 2-(4-hydroxybenzyl)butanoate | HCID 22988421 | — |
| Reactant | 2-[4-(Methylsulfonyl)phenyl]-1-ethanol | HCID 22988427 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Triphenylphosphine Oxide | HCID 13097 | — |
Reaction Steps
Methyl 2-(4-hydroxybenzyl)butanoate (0.50 g; 2.5 mmole) and 2-[4-(methylsulfonyl)phenyl]ethanol (0.52 g, 2.5 mmole) were mixed in dichloromethane (10 ml). ADDP (0.76 g, 3.0 mmole) was added followed by addition of triphenylphosphine ((0.79 g, 3.0 mmole). The reaction was interrupted after 16 hours. Triphenylphosphine oxide formed in the reaction was filtered off and the filtrate was evaporated. Chromatography of the crude material from methanol and dichloromethane, gradient eluation from 0-32% gave 0.64 g (66% yield) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06630509B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-8338b72c4c834992ae4b275bc0af7d9b |
| Source note | uspto-grants-2003_10 |