HRID987152

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11776

Triphenylphosphine

C18H15P

HCID73042

1,1′-(1,2-Diazenediyl)bis[1-(1-piperidinyl)methanone]

C12H20N4O2

HCID11413715

N-Boc-2-(4-aminophenyl)ethanol

C13H19NO3

HCID11791243

Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate

C13H18O4

PRODUCTS

生成物

结构：CCOC(=O)C(Cc1ccc(OCCc2ccc(NC(=O)OC(C)(C)C)cc2)cc1)OCC

HCID22988408

未命名化合物

收率 89.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Compound (c) (1.03 g; 4.34 mmole) and (b) (1.03 g; 4.34 mmole) were dissolved in dichloromethane under argon at room temperature. Azodicarbonyl dipiperidine (1.65 g; 6.5 mmole) and thereafter triphenylphosphine (1.37 g; 5.2 mmole) were added. After stirring at room temperature for 6 hours the solvent was evaporated in vacuo. Purification by chromatography on silica gel using heptane:ethyl acetate (2:1) as eluant gave 1.78 g (yield 89%) of the desired product

WORKUP

后处理

customwas evaporated in vacuo
customPurification by chromatography on silica gel

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7fc15b0fa71240d9942823658db18c53
来源数据集: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06630509B2
来源说明: uspto-grants-2003_10

反应 SMILES

[C:1]([O:5][C:6](=[O:17])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:18]([O:20][CH:21]([CH2:27][C:28]1[CH:33]=[CH:32][C:31](O)=[CH:30][CH:29]=1)[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH3:19].N(C(N1CCCCC1)=O)=NC(N1CCCCC1)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[C:1]([O:5][C:6]([NH:7][C:8]1[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][O:16][C:31]2[CH:30]=[CH:29][C:28]([CH2:27][CH:21]([O:20][CH2:18][CH3:19])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:33][CH:32]=2)=[CH:12][CH:13]=1)=[O:17])([CH3:4])([CH3:2])[CH3:3]