2-[(3-Nitro-4-quinolinyl)amino]ethanol → HCID 13958348, compound

HRID 987189Notes

Reaction equation

HRID 987189 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][CH2:16][OH:17])=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O>[Pt].C(O)C>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][CH2:16][OH:17])=[CH:11][CH:10]=[CH:9][CH:8]=2

Participants

4

Reactant 1

HCID 130073542-[(3-Nitro-4-quinolinyl)amino]ethanol

Product 1

HCID 13958348HCID 13958348, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 702EthanolSolvent

Procedure

2-[(3-Nitro4-quinolinyl)amino]ethanol (6 g) was combined with ethanol (200 mL) and platinum on carbon catalyst. The mixture was hydrogenated on a Parr apparatus. This procedure was repeated four additional times using a total of 30 g of starting material. The mixtures from all five hydrogenations were combined and then filtered through a layer of Celite® filter aid to remove the catalyst. The filtrate was concentrated under vacuum to provide crude 2-[(3-amino-4-quinolinyl)amino]ethanol.

Workup

  1. filtrationfiltered through a layer of Celite®
  2. filtrationfilter aid
  3. customto remove the catalyst
  4. concentrationThe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-e4c6a991ae1f4abaaed806ad63c80912
Source dataset
uspto-grants-2003_10
Patent number
US06630588B2

Reaction notes

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