Ethanol → [3-(4-Bromo-benzyl)-3H-imidazol-4-YL]-methanol

HRID 987200Notes

Reaction equation

[Br:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[C:8]2S)=[CH:4][CH:3]=1.C(O)C.OO.[OH-].[Na+]>O.[O-]S([O-])(=O)=O.O=[V+2].O>[Br:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[C:11]([CH2:12][OH:13])=[CH:10][N:9]=[CH:8]2)=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 45 °C

Procedure

1-(4-Bromobenzyl)-2-mercapto-5-hydroxymethylimidazole(40 g, 0.134 mol) and vanadyl sulfate hydrate(21.9 mg, 0.1 mol %) were introduced into a mixed solution of 240 ml of ethanol and 240 ml of water. The mixture was warmed to 45° C. and stirred. After a short time, 30% hydrogen peroxide(51.6 g, 3.4 molar eq.) was slowly added dropwise thereto and the internal temperature was kept at about 50° C. When the initial white suspension turned to a pale yellow solution, the solution was further stirred for about 30 minutes to which was added 6 N sodium hydroxide solution to adjust pH of the solution to about 10. Then, ethanol was distilled under reduced pressure The precipitated crystal was filtered, washed with distilled water and dried to the constant weight to give 28.7 g(Yield 80.4%, HPLC=97%) of the title compound as a white powder.

Workup

customwas kept at about 50° C
stirringthe solution was further stirred for about 30 minutes to which
distillationThen, ethanol was distilled under reduced pressure The precipitated crystal
filtrationwas filtered
washwashed with distilled water
customdried to the constant weight

Sources & evidence

ORD record: ord-b276dcf67961410fab452b5f614ead68
Source dataset: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06630593B1

Reaction notes

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