3-(4-Benzyloxyphenyl)-2-methoxypropanoic acid methyl ester → Methyl 3-(4-hydroxyphenyl)-2-methoxypropanoate

HRID 987239Notes

Reaction equation

HRID 987239 reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH:4]([O:20][CH3:21])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]CC2C=CC=CC=2)=[CH:8][CH:7]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:22])[CH:4]([O:20][CH3:21])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1

Participants

4

Reactant 1

HCID 126160413-(4-Benzyloxyphenyl)-2-methoxypropanoic acid methyl ester

Product 1

HCID 10965756Methyl 3-(4-hydroxyphenyl)-2-methoxypropanoateYield 87%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3-(4-Benzyloxyphenyl)-2-methoxypropanoic acid methyl ester (1.91 g; 6.36 mmole) was hydrogenated in methanol (30 ml) using Pd/C (5%, wet, 0.9 g) as catalyst. The mixture was filtered through celite and the filtrate was evaporated in vacuo to give 1.16 g (yield 87%) of 3-(4-hydroxyphenyl)-2-methoxypropanoic acid methyl ester.

Workup

  1. filtrationThe mixture was filtered through celite
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-1c9d470edc554c7aa88194000e7fb9be
Source dataset
uspto-grants-2003_10
Patent number
US06630600B1

Reaction notes

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