Methyl 3-(4-hydroxyphenyl)-2-(2,2,2-trifluoroethoxy)propanoate → 3-[4-(2-{4-tert-Butoxycarbonylaminophenyl}ethoxy)phenyl]-2-(2,2,2-trifluoroethoxy)propanoic acid methyl ester

HRID 987303Notes

Reaction equation

HRID 987303 reaction equation
[CH3:1][O:2][C:3](=[O:19])[CH:4]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[C:20]([O:24][C:25](=[O:36])[NH:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][CH2:34]O)=[CH:29][CH:28]=1)([CH3:23])([CH3:22])[CH3:21]>>[CH3:1][O:2][C:3](=[O:19])[CH:4]([O:13][CH2:14][C:15]([F:16])([F:18])[F:17])[CH2:5][C:6]1[CH:7]=[CH:8][C:9]([O:12][CH2:34][CH2:33][C:30]2[CH:29]=[CH:28][C:27]([NH:26][C:25]([O:24][C:20]([CH3:21])([CH3:23])[CH3:22])=[O:36])=[CH:32][CH:31]=2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 10858799Methyl 3-(4-hydroxyphenyl)-2-(2,2,2-trifluoroethoxy)propanoateHCID 11413715N-Boc-2-(4-aminophenyl)ethanol

Product 1

HCID 571530703-[4-(2-{4-tert-Butoxycarbonylaminophenyl}ethoxy)phenyl]-2-(2,2,2-trifluoroethoxy)propanoic acid methyl ester

Procedure

3-[4-(2-{4-tert-Butoxycarbonylaminophenyl}ethoxy)phenyl]-2-(2,2,2-trifluoroethoxy)propanoic acid methyl ester was synthesized using the same method as in Example 62 (a) from 3-(4-hydroxyphenyl)-2-(2,2,2-trifluoroethoxy)propanoic acid methyl ester and 4-(2-hydroxyethyl)phenylcarbamic acid tert-butyl ester(described in Example 38b.

Sources & evidence

ORD record
ord-9a9ab827326d4e4cb3b0e69bac2b07e1
Source dataset
uspto-grants-2003_10
Patent number
US06630600B1

Reaction notes

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