Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 987303Generated: October 30, 2026

Methyl 3-(4-hydroxyphenyl)-2-(2,2,2-trifluoroethoxy)propanoate → 3-[4-(2-{4-tert-Butoxycarbonylaminophenyl}ethoxy)phenyl]-2-(2,2,2-trifluoroethoxy)propanoic acid methyl ester

https://huagongshe.com/reaction/987303

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-(4-hydroxyphenyl)-2-(2,2,2-trifluoroethoxy)propanoateHCID 10858799—
ReactantN-Boc-2-(4-aminophenyl)ethanolHCID 11413715—
Product3-[4-(2-{4-tert-Butoxycarbonylaminophenyl}ethoxy)phenyl]-2-(2,2,2-trifluoroethoxy)propanoic acid methyl esterHCID 57153070—

Reaction Steps

3-[4-(2-{4-tert-Butoxycarbonylaminophenyl}ethoxy)phenyl]-2-(2,2,2-trifluoroethoxy)propanoic acid methyl ester was synthesized using the same method as in Example 62 (a) from 3-(4-hydroxyphenyl)-2-(2,2,2-trifluoroethoxy)propanoic acid methyl ester and 4-(2-hydroxyethyl)phenylcarbamic acid tert-butyl ester(described in Example 38b.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06630600B1
Source datasetuspto-grants-2003_10
ORD IDord-9a9ab827326d4e4cb3b0e69bac2b07e1
Source noteuspto-grants-2003_10