[3-nitro-4-(trifluoromethyl)phenyl]methanol → [3-amino-4-(trifluoromethyl)phenyl]methanol

HRID 987383Notes

Reaction equation

HRID 987383 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:14][OH:15])[CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:14][OH:15])[CH:7]=[CH:8][C:9]=1[C:10]([F:11])([F:12])[F:13]

Participants

4

Reactant 1

HCID 11287467[3-nitro-4-(trifluoromethyl)phenyl]methanol

Product 1

HCID 11171505[3-amino-4-(trifluoromethyl)phenyl]methanolYield 86.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The product from Example 4A (3.6 g, 16.28 mmol) in methanol (100 mL) was hydrogenated in the presence of a catalytic amount of Pd /C for 4 hours. The catalyst was filtered off and the volatiles were evaporated to yield 2.7 g of the title compound.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe volatiles were evaporated

Sources & evidence

ORD record
ord-194c1c009b30450cb99fbf0dda96abe5
Source dataset
uspto-grants-2003_10
Patent number
US06632418B2

Reaction notes

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