Ammonia → Methyl 3-aminopent-2-enoate

HRID 987388Notes

Reaction equation

HRID 987388 reaction equation
O=[C:2]([CH2:8][CH3:9])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[NH3:10]>C(O)C>[NH2:10][C:2]([CH2:8][CH3:9])=[CH:3][C:4]([O:6][CH3:7])=[O:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 121699Methyl 3-oxovalerate

Product 1

HCID 57860398Methyl 3-aminopent-2-enoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

Methyl 3-oxopentanoate (10 g, 77 mmol) was treated with 2M ammonia in ethanol (200 mL), heated at 80° C. in a sealed tube for 16 hours and concentrated to dryness to provide the title compound.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-518da671a7264f91a9464ab472c00381
Source dataset
uspto-grants-2003_10
Patent number
US06632418B2

Reaction notes

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