Ethyl 3-(5,6,7-trimethoxynaphthalen-2-yl)propenoate → Ethyl 3-(5,6,7-trimethoxynaphthalen-2-yl)propionate

HRID 987422Notes

Reaction equation

HRID 987422 reaction equation
[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[C:11]([O:15][CH3:16])[CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][C:7]([CH:17]=[CH:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:8]2>CO.[Pd]>[CH3:1][O:2][C:3]1[C:12]([O:13][CH3:14])=[C:11]([O:15][CH3:16])[CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][C:7]([CH2:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:8]2

Participants

4

Reactant 1

HCID 68436859Ethyl 3-(5,6,7-trimethoxynaphthalen-2-yl)propenoate

Product 1

HCID 21891562Ethyl 3-(5,6,7-trimethoxynaphthalen-2-yl)propionate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Ethyl 3-(5,6,7-trimethoxynaphthalen-2-yl)propenoate (1.70 g) was dissolved in methanol (20 mL), 10% palladium on carbon (510 mg) was added to the solution, and the mixture was stirred at room temperature for 2.5 hours under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was then concentrated to obtain the title compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was then concentrated

Sources & evidence

ORD record
ord-5521fe97ec2940168d1d875d1077ade8
Source dataset
uspto-grants-2003_10
Patent number
US06632810B2

Reaction notes

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