2-Hydroxymethyl-1-methyl-4,5,6-trimethoxyindole → 1-Methyl-4,5,6-trimethoxyindole-2-carboaldehyde

Participants

Reaction Steps

2-Hydroxymethyl-1-methyl-4,5,6-trimethoxyindole (861 mg) was dissolved in benzene (50 mL), activated manganese dioxide (8.7 g) was added to the solution, and the mixture was stirred at room temperature for 2 hours. After the reaction mixture was filtered, and the filtrate was concentrated, the residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:2) to obtain the title compound.

Provenance & Evidence