Ethanol → N-Ethoxycarbonyl-2-nitro-3,4,5-trimethoxyaniline

HRID 987452Notes

Reaction equation

HRID 987452 reaction equation
[N+:1]([C:4]1[C:12]([O:13][CH3:14])=[C:11]([O:15][CH3:16])[C:10]([O:17][CH3:18])=[CH:9][C:5]=1C(O)=O)([O-:3])=[O:2].C([N:21]([CH2:24]C)CC)C.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:33])C=CC=CC=1.[CH2:43]([OH:45])[CH3:44]>C1C=CC=CC=1>[CH2:43]([O:45][C:24]([NH:21][C:5]1[CH:9]=[C:10]([O:17][CH3:18])[C:11]([O:15][CH3:16])=[C:12]([O:13][CH3:14])[C:4]=1[N+:1]([O-:3])=[O:2])=[O:33])[CH3:44]

Participants

6

Reactant 4

HCID 702EthanolHCID 8471TriethylamineHCID 971163,4,5-Trimethoxy-2-nitrobenzoic acidHCID 199401P,P-Diphenylphosphinic azide

Product 1

HCID 21891612N-Ethoxycarbonyl-2-nitro-3,4,5-trimethoxyaniline

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2-Nitro-3,4,5-trimethoxybenzoic acid (4.7 g) was dissolved in dry benzene (70 mL), triethylamine (2.56 mL) and diphenylphosphoryl azide (4.15 mL) were added to the solution, and the mixture was stirred for 2 hours under reflux. Dry ethanol (140 mL) was added to the reaction mixture, and the mixture was further stirred overnight under reflux. After the reaction mixture was concentrated under reduced pressure, the residue was extracted with ethyl acetate. The resultant organic layer was washed with diluted hydrochloric acid, an aqueous solution of potassium carbonate, water and saturated brine, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:4 to 1:3) to obtain the title compound.

Workup

  1. temperatureunder reflux
  2. waitthe mixture was further stirred overnight
  3. temperatureunder reflux
  4. concentrationAfter the reaction mixture was concentrated under reduced pressure
  5. extractionthe residue was extracted with ethyl acetate
  6. washThe resultant organic layer was washed with diluted hydrochloric acid
  7. dry with materialan aqueous solution of potassium carbonate, water and saturated brine, dried over anhydrous magnesium sulfate
  8. concentrationconcentrated under reduced pressure
  9. customThe residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:4 to 1:3)

Sources & evidence

ORD record
ord-78a2ab63c7a547b98778f090070c5920
Source dataset
uspto-grants-2003_10
Patent number
US06632810B2

Reaction notes

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