HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-(4-nitrophenyl)-1,4-diazepane-1-carboxylate → Tert-butyl 4-(4-aminophenyl)-1,4-diazepane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-(4-nitrophenyl)-1,4-diazepane-1-carboxylate | HCID 18008978 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Tert-butyl 4-(4-aminophenyl)-1,4-diazepane-1-carboxylate | HCID 18008968 | — |
Reaction Steps
1-Boc-4-(4-nitrophenyl)homopiperazine (prepared with 1-fluoro-4-nitrobenzene, 1-Boc-homopiperazine, Cs2CO3 in heated DMF) was dissolved in methanol. To it was added 10% Pd/C. The slurry was stirred under a hydrogen balloon for 2 hrs. It was filtered through celite and evaporated in vacuuo to give 1-(4-aminophenyl)-4-Boc-homopiperazine. ES-MS: (M+H)+292.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06632815B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-41465f5e931641b6b84f6b9c4761113b |
| Source note | uspto-grants-2003_10 |