HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-[3-(3,4-Dichlorophenyl)-8-azabicyclo[3.2.1]oct-2-en-8-yl]propoxy-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 3-(3,4-Dichlorophenyl)-2-nortropene | HCID 10220657 | — |
| Reactant | 4-(3-chloropropoxy)-1H-indole | HCID 11694169 | — |
| Product | 3-[3-(3,4-Dichlorophenyl)-8-azabicyclo[3.2.1]oct-2-en-8-yl]propoxy-1H-indole | HCID 86587298 | — |
Reaction Steps
The title compound is prepared according to the procedure of Example 2, Step 3, except that 4-(3-chloropropoxy)-1H-indole is used in place of 4-(2-chloro-ethoxy)-1H-indole and 3-(3,4-dichloro-phenyl)-8-aza-bicyclo[3.2.1]oct-2-ene is used in place of 3-(8-aza-bicyclo[3.2.1]oct-2-en-3-yl)-1H-indole. The corresponding oxalate salt is prepared by treating the title compound with 1 equiv. of oxalic acid in EtOH. Yield: 22% of an off-white solid. mp: 150-153° C.; MS (ES) m/z: 427.2 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06632824B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-de4f7caabf5540f183f3b851a93308ef |
| Source note | uspto-grants-2003_10 |