HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic Acid → 8-{2-[3-(2-Naphthyl)-8-azabicyclo[3.2.1]oct-8-yl]ethoxy}quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 8-Hydroxyquinoline | HCID 1923 | — |
| Reactant | 6-Methoxyquinolin-8-ol | HCID 18009170 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-{2-[3-(2-Naphthyl)-8-azabicyclo[3.2.1]oct-8-yl]ethoxy}quinoline | HCID 10201518 | — |
Reaction Steps
The title compound is prepared according to Example 8, Step 5, except 8-hydroxyquinoline is used in place 6-methoxyquinolin-8-ol. The corresponding oxalate salt is prepared by treating the title compound with 1 equiv. oxalic acid in DMF to precipitate a white solid. Yield: 51%; mp: 110-113° C.; MS (ES) m/z: 409 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06632824B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-a697807a9ca2483d89acf66924cb416c |
| Source note | uspto-grants-2003_10 |