反应详情

A mixture of 1.07 g (3.00 mmol) of 2-(4-benzyloxy-3-propoxyphenyl)-5,5-dimethyl-1,3-dioxane, 15 ml of tetrahydrofuran and 107 g of 10% palladium/C hydrogenation catalyst was hydrogenated at room temperature. After the absorption of 62.4 ml of hydrogen, the reaction suspension was filtered through Dicalite and evaporated down. Chromatography of the residue over 25 g of silica gel using 19:1 toluene/ethyl acetate gave 790 mg of 4-(5,5-dimethyl-1,3-dioxan-2-yl)-2-propoxyphenol.

1. customwas hydrogenated at room temperature
2. customAfter the absorption of 62.4 ml of hydrogen
3. filtrationthe reaction suspension was filtered through Dicalite
4. customevaporated down