3(E)-[4-Ethoxy-3-Propoxyphenyl]Acrylic Acid → HCID 22987079, compound

HRID 987874Notes

Reaction equation

HRID 987874 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[C:12]([OH:14])=[O:13])=[CH:6][C:5]=1[O:15][CH2:16][CH2:17][CH3:18])[CH3:2]>C1(C)C=CC=CC=1.C(OCC)(=O)C>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[C:12]([O:14][CH2:9][CH2:4][CH2:5][CH2:6][CH2:7][CH2:10][CH2:11][CH2:12][OH:13])=[O:13])=[CH:6][C:5]=1[O:15][CH2:16][CH2:17][CH3:18])[CH3:2]

Participants

3

Reactant 1

HCID 177755763(E)-[4-Ethoxy-3-Propoxyphenyl]Acrylic Acid

Product 1

HCID 22987079HCID 22987079, compound

Reagents, catalysts & solvents 1

HCID 21584019Toluene ethylacetateSolvent

Procedure

The preparation is carried out analogously to Example 1 from 1.0 g (4.00 mmol) of 3(E)-[4-ethoxy-3-propoxyphenyl]acrylic acid and 0.92 g (4.39 mmol) of 8-bromo-1-hexanol and, according to chromatography over 150 g of silica gel using toluene/ethyl acetate, gives 8-hydroxyoctyl 3(E)-[4-ethoxy-3-propoxyphenyl]acrylate.

Sources & evidence

ORD record
ord-2a9110554822438e8b189f15aec5e95f
Source dataset
uspto-grants-2003_10
Patent number
US06632909B2

Reaction notes

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