HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S)-4-Amino-N-(4-amino-1-hydroxymethyl-butyl)-N-isobutyl-benzenesulfonamide → (1S,4S)-(1-{4-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-5-hydroxy-pentylcarbamoyl}-2-naphthalen-1-yl-ethyl)-carbamic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S)-4-Amino-N-(4-amino-1-hydroxymethyl-butyl)-N-isobutyl-benzenesulfonamide | HCID 12986160 | — |
| Reactant | (2S)-2-methoxycarbonylamino-3-naphthalen-1-yl-propionic acid | HCID 12986162 | — |
| Product | (1S,4S)-(1-{4-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-5-hydroxy-pentylcarbamoyl}-2-naphthalen-1-yl-ethyl)-carbamic Acid Methyl Ester | HCID 513924 | — |
Reaction Steps
The title compound was prepared from general procedure A using (2S)-2-methoxycarbonylamino-3-naphthalen-1-yl-propionic acid and amine intermediate VII. The final product was obtained in 76% yield. Rf=0.57, EtOAc 100%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06632816B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-c7f58c981ac946319b6c03b59409c41a |
| Source note | uspto-grants-2003_10 |