HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S)-4-Amino-N-(4-amino-1-hydroxymethyl-butyl)-N-isobutyl-benzenesulfonamide → N-[(1S)-1-[[(4S)-4-[(4-aminophenyl)sulfonyl-isobutyl-amino]-5-hydroxy-pentyl]carbamoyl]-2,2-diphenyl-ethyl]morpholine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S)-4-Amino-N-(4-amino-1-hydroxymethyl-butyl)-N-isobutyl-benzenesulfonamide | HCID 12986160 | — |
| Reactant | (2s)-2-[(Morpholine-4-carbonyl)-amino]-3,3-diphenyl-propionic acid | HCID 12986168 | — |
| Product | N-[(1S)-1-[[(4S)-4-[(4-aminophenyl)sulfonyl-isobutyl-amino]-5-hydroxy-pentyl]carbamoyl]-2,2-diphenyl-ethyl]morpholine-4-carboxamide | HCID 513931 | — |
Reaction Steps
The title compound was prepared from general procedure A using (2S)-2-[(morpholine-4-carbonyl)-amino]-3,3-diphenyl-propionic acid and amine intermediate VII. The final product was obtained in 36% yield. Rf=0.15 EtOAc 100%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06632816B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-30b78349ba55459aa32aa504198a84de |
| Source note | uspto-grants-2003_10 |