HRID987946

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)N[C@H](C(=O)O)C(c1ccccc1)c1ccccc1

HCID10017620

未命名化合物

结构：CC(C)CN([C@H](CO)CCCN)S(=O)(=O)c1ccc(N)cc1

HCID12986160

未命名化合物

PRODUCTS

生成物

结构：COC(=O)N[C@H](C(=O)NCCC[C@@H](CO)N(CC(C)C)S(=O)(=O)c1ccc(N)cc1)C(c1ccccc1)c1ccccc1

HCID513932

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from general procedure A using (2S)-2-methoxycarbonylamino-3,3-diphenyl-propionic acid (see example 34, step A) and amine intermediate VII. The final product was obtained in 74% yield. Rf=0.57 EtOAc 100%.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b3caa8a532fc4e15b0654d7ab53ba982
来源数据集: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06632816B1
来源说明: uspto-grants-2003_10

反应 SMILES

[CH3:1][O:2][C:3]([NH:5][C@@H:6]([CH:10]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7]([OH:9])=O)=[O:4].[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([S:30]([N:33]([C@H:38]([CH2:43][OH:44])[CH2:39][CH2:40][CH2:41][NH2:42])[CH2:34][CH:35]([CH3:37])[CH3:36])(=[O:32])=[O:31])=[CH:26][CH:25]=1>>[CH3:1][O:2][C:3](=[O:4])[NH:5][C@H:6]([C:7](=[O:9])[NH:42][CH2:41][CH2:40][CH2:39][C@H:38]([N:33]([S:30]([C:27]1[CH:26]=[CH:25][C:24]([NH2:23])=[CH:29][CH:28]=1)(=[O:32])=[O:31])[CH2:34][CH:35]([CH3:36])[CH3:37])[CH2:43][OH:44])[CH:10]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1