Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 987946Generated: October 30, 2026

(S)-2-methoxycarbonylamino-3,3-diphenyl-propionic acid → methyl N-[(1S)-1-[[(4S)-4-[(4-aminophenyl)sulfonyl-isobutyl-amino]-5-hydroxy-pentyl]carbamoyl]-2,2-diphenyl-ethyl]carbamate

https://huagongshe.com/reaction/987946

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-2-methoxycarbonylamino-3,3-diphenyl-propionic acidHCID 10017620—
Reactant(1S)-4-Amino-N-(4-amino-1-hydroxymethyl-butyl)-N-isobutyl-benzenesulfonamideHCID 12986160—
Productmethyl N-[(1S)-1-[[(4S)-4-[(4-aminophenyl)sulfonyl-isobutyl-amino]-5-hydroxy-pentyl]carbamoyl]-2,2-diphenyl-ethyl]carbamateHCID 513932—

Reaction Steps

The title compound was prepared from general procedure A using (2S)-2-methoxycarbonylamino-3,3-diphenyl-propionic acid (see example 34, step A) and amine intermediate VII. The final product was obtained in 74% yield. Rf=0.57 EtOAc 100%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06632816B1
Source datasetuspto-grants-2003_10
ORD IDord-b3caa8a532fc4e15b0654d7ab53ba982
Source noteuspto-grants-2003_10