HRID987963

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)C(Cc1cccc2ccccc12)NC(=O)N1CCOCC1

HCID18009024

未命名化合物

结构：CC(C)CN([C@H](CO)CCCCN)S(=O)(=O)c1ccc(N)cc1

HCID20595420

未命名化合物

PRODUCTS

生成物

结构：CC(C)CN([C@H](CO)CCCCNC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)N1CCOCC1)S(=O)(=O)c1ccc(N)cc1

HCID513954

未命名化合物

收率 32%

PROCEDURE

实验过程

This material was prepared from (1S)-4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-isobutyl-benzenesulfonamide (XII) (example 28, step D) as described in general procedure B using 2-[(morpholine-4-carbonyl)-amino]-3-naphthalen-1-yl-propionic acid (step A). The final product was obtained in 32% yield (33 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-58ab94a11e2746818ba90819243c52fb
来源数据集: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06632816B1
来源说明: uspto-grants-2003_10

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C@H:16]([CH2:22][OH:23])[CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH2:12][CH:13]([CH3:15])[CH3:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[N:24]1([C:30]([NH:32][CH:33]([CH2:37][C:38]2[C:47]3[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH:41]=[CH:40][CH:39]=2)[C:34](O)=[O:35])=[O:31])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:12][CH:13]([CH3:15])[CH3:14])[C@H:16]([CH2:22][OH:23])[CH2:17][CH2:18][CH2:19][CH2:20][NH:21][C:34]([C@@H:33]([NH:32][C:30]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)=[O:31])[CH2:37][C:38]2[C:47]3[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH:41]=[CH:40][CH:39]=2)=[O:35])(=[O:10])=[O:9])=[CH:4][CH:3]=1