HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[(Morpholine-4-carbonyl)-amino]-3-naphthalen-1-yl-propionic acid → N-[(1S)-2-[[(5S)-5-[(4-aminophenyl)sulfonyl-isobutyl-amino]-6-hydroxy-hexyl]amino]-1-(1-naphthylmethyl)-2-oxo-ethyl]morpholine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[(Morpholine-4-carbonyl)-amino]-3-naphthalen-1-yl-propionic acid | HCID 18009024 | — |
| Reactant | (1S)-4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-isobutyl-benzenesulfonamide | HCID 20595420 | — |
| Product | N-[(1S)-2-[[(5S)-5-[(4-aminophenyl)sulfonyl-isobutyl-amino]-6-hydroxy-hexyl]amino]-1-(1-naphthylmethyl)-2-oxo-ethyl]morpholine-4-carboxamide | HCID 513954 | 32% |
Reaction Steps
This material was prepared from (1S)-4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-isobutyl-benzenesulfonamide (XII) (example 28, step D) as described in general procedure B using 2-[(morpholine-4-carbonyl)-amino]-3-naphthalen-1-yl-propionic acid (step A). The final product was obtained in 32% yield (33 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06632816B1 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-58ab94a11e2746818ba90819243c52fb |
| Source note | uspto-grants-2003_10 |