Benzyl Bromide → HCID 69792502, compound

HRID 988037Notes

Reaction equation

[OH:1][C:2]1[C:11]2[C:10]([CH3:13])([CH3:12])[CH2:9][CH2:8][C:7]([CH3:15])([CH3:14])[C:6]=2[CH:5]=[CH:4][C:3]=1[C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][C:24]([O:26]C)=[O:25])[CH:19]=[CH:20][CH:21]=1.[CH2:28](Br)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH2:28]([O:1][C:2]1[C:11]2[C:10]([CH3:12])([CH3:13])[CH2:9][CH2:8][C:7]([CH3:14])([CH3:15])[C:6]=2[CH:5]=[CH:4][C:3]=1[C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][C:24]([OH:26])=[O:25])[CH:19]=[CH:20][CH:21]=1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 73884379HCID 73884379, compound

Product 1

HCID 69792502HCID 69792502, compoundYield 91.1%

Procedure

In a manner similar to that of Example 1(a), by reaction of 500 mg (1.37 mmol) of methyl 3-[3-(1-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)phenyl]acrylate with 180 μl (1.5 mmol) of benzyl bromide, 550 mg (88%) of the expected compound were obtained in the form of a yellow oil.

Sources & evidence

ORD record: ord-2aa8d70dc782453b8b6f806846dd021e
Source dataset: uspto-grants-2003_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06632963B1

Reaction notes

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